I meant you shouldn't in both cases.
You see, I have never met the info that alcohol is completely contraindicated with Duromine. So if you want to skip a pill it is better to wait 24 hours and then a little amount of alcohol is harmless. Not sure though, that's what people say. Some people have side effects, others don't...There are records that alcohol can increase the effect of Duromine on the CNS. Basically all the side effects from the central nervous system can increase, too. Like: restlessness, overstimulation, insomnia, nervousness, tremor, dizziness, headaches, etc. I wouldn't take that risk IMHO.
On the other hand, I have written many times that you SHOULD NOT SKIP A DOSE. Though I heard some doctors prescribe to take Duromine just for 5 days and skip the pills on the weekends. Personally I don't understand why would you do so? You know that alcohol provides relaxation and increases appetite. It means that potentially your weekend-without-the-pill may cost you ZERO WEIGHT LOSS (at best) or even SOME KILOS BACK (at worst)!!! But any guide list says you should take Duromine for 12 weeks without breaks.
I don't want to push you, Em, but you should better think twice. Is this event really so important and you really need to drink alcohol, or your weight loss is still a priority?