Duromine Side Effects: All Warnings to Keep in Mind

Duromine precautions

When you are planning a visit to your physician to ask for Duromine, you need to think thoroughly over questions that you have about Duromine action and possible side effects of Duromine. You also have to make sure that you remember all the drugs that you take at the moment or occasionally, as well as your medical history. By following these precautions for Duromine, you will be able to avoid unpleasant events and minimize your risk for serious side effects.

Duromine can interact with your prescription and OTC drugs

It is particularly important to mention all medicines and substances that you use to avoid drug-drug interaction with Duromine, including:

  • Other weight loss drugs
  • SSRIs
  • DHE nasal sprays or injections (for throbbing headaches)
  • Tricyclic antidepressants
  • Insulin
  • Oral antihyperglycemic agents
  • Sedatives
  • Adrenergic drugs
  • Anti-hypertensive medications (incl. Catapres, Aldomet and Guanethidine)
  • MAOIs
  • Thyroid hormones
  • Medicines for mental health
  • Remedies for cold or cough that contain sympathomimetics
  • Alcohol
  • Caffeine
  • Narcotic substances

Even if the medications that you take are not included in the above list, you still need to tell your doctor about them. Not every drug interaction brings serious consequences. Some require dose or administration schedule adjustment, while others should be replaced into alternatives.

However, serious interactions of Duromine with some drugs can result in severe health deterioration and irreparable health damage, including:

  • Increased blood pressure / sharp blood pressure rise
  • Irregular heart rate
  • Nervousness
  • Sleeping issues
  • Shivering
  • Edginess

Duromine should be used with caution in some conditions

In certain health conditions, Duromine should be used with caution or avoided completely. Inform your doctor, if you suffer from or have a history of the following conditions:

  • Allergy to any drugs and, in particular, to Phentermine, any ingredients that your Duromine caps contain, or any other amphetamine derivatives;
  • Any shifts in blood pressure levels;
  • Any cardiovascular diseases, both in present and earlier;
  • Diabetes or pre-diabetic condition;
  • Epilepsy.
  • Duromine is strictly contraindicated in certain conditions

Do not attempt to talk your doctor into prescribing you Duromine without informing him of any of the following conditions (that you have currently or had in the past):

  • Breastfeeding period;
  • Pregnancy or trying to conceive;
  • Very high blood pressure levels, regardless of whether controlled with drugs or not;
  • Increased blood pressure in the lungs (Pulmonary hypertension);
  • Any heart valve disorder or serious heart conditions;
  • Any cerebrovascular diseases;
  • Atherosclerosis;
  • Renal impairment;
  • Abnormal thyroid function (hyperthyroidism);
  • Any psychiatric disorder;
  • Glaucoma and intraocular hypertension;
  • Abuse or dependence on alcohol, medicines or narcotic substances

Elderly patients who decide to use Duromine to lose weight, have to make sure that their kidneys function efficiently enough to excrete the drug from the body at a sustainable rate. Otherwise, toxic reactions are possible. At that, the dose of the drug should be prescribed solely by a doctor and should not be increased, even if it is the smallest dose of 15 mg.

Potential hazards of Duromine use in certain situations

1. If you regularly drive a vehicle or operate machinery

Keep in mind that Duromine can cause dizziness, drowsiness and other side effects from the part of CNS, so you should be very careful, especially at the beginning of the course, if you are engaged in operating any complex or dangerous machinery, or drive a car on a regular basis. In such cases, it is recommended to begin taking Duromine on days, when you are not engaged in any of these activities to asses the side effects that you have and take timely measures without posing yourself or surrounding people to any threat.

2. If you are used to consuming alcohol occasionally

It is not recommended to consume alcohol while you are on Duromine, because such interaction can cause certain unpleasant reactions, including:

  • Severe hangover
  • Aggravation of side effects
  • Bounce back in the weight and loss of a weekly weight loss result

3. If you want to continue taking Duromine after the end of the 3-month course

Do not extend the anti-obesity treatment with Duromine for longer time, than recommended, i.e. 3-month period. The risk of dependence is rather high, which is why a 3-month Duromine course should be followed by at least 1- or 2-month break, after which you can resume using Duromine, if your doctor thinks you are fit to continue losing weight with this anorectic.

4. If you have a scheduled or urgent surgical intervention of any kind

No matter what kind of surgical intervention you need to have, it is VERY important that you inform your doctor about the fact that you are currently using Duromine, because any intervention requires the use of various drugs. Besides the fact that Duromine can interact with medications, it also affects your cardiovascular and pulmonary system, so its use should better be discontinued for at least 3-4 days before and after the surgery.

Who should not take Duromine?

Since Duromine is intended for use in overweight and obesity, it should not be used by people, who want to lose a couple of kilograms solely for a cosmetic purpose. This anorectic is too strong and can cause serious side effects, which are not worth it when your only weight loss goal is to fit in jeans one size smaller. You can achieve this goal through less serious measures, like reviewing your nutrition and increasing or changing the level/character of your physical activity.

Therefore, if your BMI is less than 29, and you don’t suffer from any obesity-induced co-morbidities with a BMI of 25-29.9 – you should not take Duromine.

The use of this anorectic in a comprehensive weight loss program is limited to three consecutive months. So, even though it is allowed for use in children of 12 years and older, the feasibility of its use in childhood obesity should be seriously thought-over, since the treatment of obesity and overweight in children is usually a very long-lasting process and the use of Duromine as a quick fix might become not the best idea.

Therefore, if the child did not reach the age of 12 years, and/or his overweight or obesity require a years-long slow anti-obesity therapy – he should not take Duromine.

Even though studies on Duromine safety in pregnancy were held in animals, and the significance of the fetal damage in animals was considered uncertain in people, Duromine is included in the Category B3 for drugs use in pregnancy, i.e. it has not proven to be 100% safe. Since no trials were held on the ability of this anorectic to pass into the breast milk, women are recommended to avoid breastfeeding while taking Duromine and vice versa.
Therefore, if you are breastfeeding or pregnant, or are trying to conceive a child – you should not take Duromine.

Duromine has a strong potency for interacting with multiple drugs and alter their effects, just the same as various drugs can affect the way that Duromine acts on our body and the way our body copes with side effects. MAO inhibitors and other weight loss pills taken together with Duromine can significantly undermine your health.
Therefore, if you took any MAO inhibitor within the last 2 weeks or any other weight loss medication – you should not take Duromine.

Serious health conditions can be incompatible with Duromine use, and it is critical to tell your doctor about any disease or health problem that you have or had in the past. Do not hide any information from your prescribing physician and make sure to check the list of contraindications, warnings and precautions for Duromine to make sure that you can use this weight loss drug.

Therefore, if you have any serious health condition that is a contraindication to the use of this anorectic – you should not take Duromine.

It is possible that you have no contraindications, and your BMI is high enough to be prescribed Duromine. You take the prescription, buy Duromine, follow the dosing regimen and side effects hit you hard. You notice that your extremities are swollen, you find it hard to breathe and it seems to you that your heart is about to jump out of your chest, or you get any other side effect that manifests in a severe form. It means that your body cannot tolerate the action of Duromine, which can result into serious health deterioration.

Therefore, if you get severe side effects from Duromine use, and you need to apply for medical help to address the issue – you should not take Duromine.

This is not a full list of Precautions for Duromine use that should be considered before anyone begins taking Duromine. Remember that your health is in your hands and inform your doctor about any single health issue that you have and any single medication that you take to help him take the right decision about prescribing your Duromine.

Who can take Duromine?

Bottom line, this appetite suppressant is recommended for use in overweight and obese people, who

  • are 12 years old or more, but less than 60-65 (depending on the kidney function);
  • according to their Body Mass Index fall under the category overweight and have high obesity-induced risks for cardiovascular diseases, IR diabetes mellitus or pre-diabetes;
  • according to their Body Mass Index fall under the category obesity of any degree;
  • tried losing weight through proper nutrition and physical activity, but failed.

The decision on your appropriateness for a Duromine anti-obesity course shall be made by the prescribing physician, who needs to assess your overall health condition, weight, height and age, as well as take into account the precautions for Duromine use and make sure that you can use it without a health threat.

If the doctor considers you a proper candidate for the use of Duromine, he:

  • issues a prescription, which should contain the dosage and dosing schedule for Duromine,
  • provides you with recommendations on nutrition and physical activity,
  • schedules the next check-up visit, required to properly monitor your health condition, weight loss process and to prescribe you the next Duromine package, if appropriate.
  • explains everything about the proper procedure for Duromine discontinuation, when you get a prescription for the finishing month on Duromine.

Duromine side effects

Having studied Duromine success stories and reviewed the Poll on most frequent side effects, people who plan on using Duromine to boost weight loss wonder what other side effects they can have and what to do to avoid or cope with insomnia on Duromine, as well as other side effects, if they do manifest.

While providing a beneficial appetite suppressing effect and pleasing its users with its high effectiveness, Duromine remains a potent drug, the use of which requires careful attention and cautiousness.

The first protective barrier is your doctor, who, before prescribing this drug to you, should assess your health indicators and, based on these, take a decision on Duromine safety for your body. At this step, it is extremely important to check the list of Precautions for Duromine use and make sure that you are not contraindicated to use it.

The second protective barrier is your own attitude towards your weight loss and readiness to observe certain rules for Duromine use, which include compliance with the dosing schedule and treatment duration, increased water intake, proper nutrition, giving up alcohol and adequate physical activity.

The third protective barrier is your own body and the way it responses to Duromine action. This is the point, where you literally have to wait for the mild side effects to subside and immediately seek medical help in case of severe side effects.

Most frequent side effects of Duromine

While it is impossible to tell anyone which side effects he/she will have and when they will subside, you can inform yourself on which side effects, both mild and severe, you can have when you take Duromine:

  • Dry mouth
  • Headaches
  • Insomnia
  • Unpleasant taste in the mouth
  • Constipation
  • Diarrhea
  • Dizziness
  • Mood swings
  • Changes in libido
  • Palpitations
  • Cramps
  • Nausea

If you wish and have some free time, you can cast your vote in the poll on side effects of Duromine, and see how many people had the same adverse events as you do. If you take a closer look at the results, you will notice that dry mouth stands above the rest of side effects, followed by insomnia, with headaches and constipation sharing the bronze medal.

At that, it does not mean that you will have any of these side effects at all. Still, it is very important to monitor your health condition and inform your doctor about any concerning signs, including:

  • Sharp rise in blood pressure
  • Racing heart
  • Severe rage
  • Explosive irritability
  • Depression
  • Disorientation
  • Klutziness
  • Visual, audio, tactile hallucinations

Dangerous side effects of Duromine, possible in both proper use and overdose

Seek medical health immediately, if you notice any of the following:

  • Chest pain
  • Fast or irregular heart beat
  • Difficulty in breathing
  • Weakness or fainting
  • Swelling of your arms, legs, tongue, etc.
  • Shaking arms and/or legs
  • Numb or tingling feeling in the extremities

Since side effects are quite serious, many people question, whether they should begin using Duromine or not. This makes up a very important issue that should be discussed with the prescribing physician and is one of the reasons for the need of regular doctor check ups.

How can I overcome side effects of Duromine?

Duromine effectiveness for weight loss is undeniable, based on dozens of years of a successful use of its active substance, Phentermine. Duromine, however, already has its own history of postmarketing surveillance and reports from its users about side effects that it causes.

Compliance with Duromine precautions can save you from severe side effects and minimize possible negative effects during the anti-obesity course, as well. Still, the list of side effects includes quite a few conditions that manifest in the majority of cases and can be transferred into the category of common side effects.

Duromine users try fighting and minimizing them with every possible method and below you will find solutions to frequent side effects.

Dry mouth (Xerostomia)

The majority of Duromine users report cotton mouth as the first side effect that they get when taking the first pill. This condition can last until the end of the course or just a couple of days/weeks during the course. Some users say they never felt it at all.

However, this very side effect is somewhat a useful one, since it reminds of the need to consume more water. It can be quite unpleasant at times and results in swollen tongue and bad breath. Solutions for dry mouth on Duromine:

  • Consume larger amounts of water when you feel your mouth getting dry
  • Rinse your mouth with water or suck on ice cubes
  • Consume products that stimulate saliva secretion, like sour fruits, chewy vegetables, hard cheese varieties
  • Chew sugar-free gum

Choose the solution that is the most appealing to you or use all 4, based on their convenience during the day.


Another frequent side effect that can manifest at any time during the slimming course and lasts for an undefined time. As a rule, they occur in the afternoon and in the early days of the course. Solutions for headaches on Duromine:

  • Use a pain reliever*
  • Wait some time for the pain to go away
  • Drink more water, because headache is a frequent symptom of dehydration

*Before taking any pain reliever, consult with a pharmacist or your doctor, because Duromine has a long list of worrisome and dangerous drug interactions.


Just like the headaches, sleeplessness can become a reason for Duromine discontinuation. Not every person is capable of enduring 3-4 days without a decent night’s sleep. As a rule, insomnia subsides by day 3-5 from the beginning of Duromine course. You can use some tips to fight insomnia that we gathered for you. In addition, solutions for insomnia on Duromine include:

  • Take your Duromine at the earliest possible hour in the morning
  • Use sleeping pills
  • Wait a couple of days for the sleeplessness to go away
  • Stop taking Duromine for 3-4 days and restart its use (high possibility of no insomnia at the restart)

The most comfortable and efficient dosing schedule for Duromine is an individual thing. If you find it best to take it at 9 AM – it’s fine, if you decide on taking it at 5 AM and it provides a sufficient appetite suppressant effect throughout the entire day – you’re welcome to do so.

Not every person manages to find a relief from insomnia through sleeping pills. However, it is important to always tell the doctor or pharmacist that you are on Duromine, when you are buying a sleeping aid.

Dizziness and nausea

Definitely, this couple of side effects is among the nastiest ones. Solutions for dizziness and nausea:

  • Wait some time for them to subside
  • Make sure that you consume a sufficient amount of water
  • Make sure that you consume a sufficient amount of food
  • Eat something light when you take the pill (non-sweet yogurt, half a boiled egg, etc.)

Just like the previous two, these side effects tend to alleviate by the end of the first week on Duromine, as our body adapts to the drug action. However, they are also possible because of insufficient feeding and hydration. Always make sure that you eat and drink enough while on Duromine.

Starvation can lead to far worse side effects than nausea and dizziness.


Not every person on Duromine is bold enough to discuss this delicate problem with a large audience. However, it is important to discuss every side effect that manifest while you are taking this anorectic. Keep in mind that constipation is not simply uncomfortable with its bloating, heaviness and pains – it also is capable of hindering your weight loss progress. Solutions for constipation on Duromine:

  • Increase your daily water consumption and add more fiber-rich foods into your daily menu
  • Eat some prunes or 1-2 kiwis, or drink prune juice
  • Take laxatives

As a rule, these recommendations are provided by more experienced Duromine users. If it’s just your second day of no bowel movements, try increasing (or lowering, if you suddenly began consuming too much) fiber and water. The next day, or in that very day, you can start consuming natural products that help loosen stools.

If none of these simple steps help, and you don’t feel any relief, take a good laxative. In more severe cases, people resort to enemas. Do not hesitate to discuss this problem with your doctor, if it gets too serious.


If your daily activity includes operating any complex or dangerous machinery or driving a car, it is recommended to start taking Duromine on your day off, to make sure that drowsiness and dizziness are not among the side effects that manifest in your particular case. Giving your body a couple of days to adapt to the action of Duromine can save you from unfortunate events. Play it safe!


  • Every time you go on Duromine, you need to have your health checked before the doctor gives you a prescription
  • Every time you go on Duromine, side effects that you have can be totally different from the ones that you had previously
  • Every time you go on Duromine, the appetite suppressing effect can be lower or manifest in a different way
  • Every time you go on Duromine, you should make it a part of a comprehensive weight loss program with proper nutrition + exercising/increased daily activity + lifestyle changes
  • Every time you go on Duromine, you can have different weight loss results. If you notice no effects at all, your body might become “immune” to Duromine, and you might need to stop taking it.

Stopping Duromine and possible withdrawal side effects

Before the beginning of an anti-obesity course with Duromine, many people wonder if there is any certain scheme they should follow in the end of the course to avoid unpleasant sensations, linked to Duromine discontinuation. Yes, withdrawal side effects are possible, when you:

  • Stop taking Duromine cold turkey
  • Have been taking Duromine for too long (more than 3 months)
  • Have been taking Duromine in doses that exceed the recommended dose
  • Have an increased sensitivity to the drug effect and develop dependence

Basic recommendations for Duromine cessation

First thing to remember about the course of this anorectic is to comply with the recommended daily dosages and not extend the recommended 3-month period of use. If you follow these recommendations, you already minimize the risk of any possible withdrawal effects after the end of Duromine course, including:

  • Rage
  • Overexcitement
  • Fatigue
  • Exhaustion
  • Behavior changes
  • Depressed state
  • Serious psychological disorder
  • Disturbed sleep
  • Quivering
  • Sickness
  • Stomachache
  • Skin conditions

Prevent withdrawal syndrome after Duromine discontinuation

Another important point to keep in mind even before you start taking Duromine is that you SHOULD NOT USE IT, if you have a history of alcohol or drug abuse or dependence. If you do have such a history, you immediately fall into the category with a highly increased risk of developing dependence to Duromine and, certainly, serious problems with its discontinuation.

If it happens so that you have neglected the above recommendations, you need to discuss with your doctor a plan for a gradual Duromine discontinuation. If you simply stop taking it, you might suffer from a severe withdrawal syndrome.

When Duromine stops working

People, who comply with all precautions for Duromine use, rarely report of any unpleasant symptoms when they stop Duromine. In fact, the majority find it quite easy to discontinue Duromine, especially when their body develops tolerance to the drug. This means that you no longer feel any effects, when you take this anorectic. Should this happen to you, DO NOT double the dose. You need to stop taking it.

Is Duromine safe?

Safety of this effective appetite suppressant is one of the burning issues on every forum about Duromine or Phentermine. This is explained by the fact that the list of possible side effects of Duromine is quite long and may raise certain worries in people, who are planning to use this weight loss drug.

As you already know, its active ingredient, Phentermine, has been on the market since the 60’s of the previous century and has its own history, which includes ups and downs in the popularity of this drug and, consequently, a decline in a blind belief of its undeniable safety.

Many people heard of the story, when a Phentermine-containing drug was involved into a large-scale scandal, which was centered around the reports that the drug was causing damage to heart valves. In fact, it was the second active ingredient of the drug Fen-Phen – Fenfluramine – that was causing the heart valves damage, and not Phentermine. Despite this, many doctors nowadays scare their patients with this fact, claiming it is Phentermine (Duromine) that can “make holes” in the hearts of people who use it.

However, multiple success stories about weight loss with Duromine show that its effectiveness outweighs discomfort of side effects and truly does help people become healthier and happier. The main thing is to comply with the dosing schedule, doctor’s recommendations and not abuse the drug.